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Coach trips from Santiago to La Serena

from £7.99

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Bus stations and stops in Santiago

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Frequently asked questions

Starting rates for a trip from Santiago to La Serena are at £7.99. Maximize your savings on FlixBus tickets by venturing during non-peak times and weekdays. Secure your ticket conveniently via this website or our app. Multiple secure payment options are at your disposal, including card payments, PayPal, Google Pay, among others. Check out all your options in the payment segment. Facing payment glitches? Our payment assistance page is here to help. For those buying tickets onboard or at selling points, cash remains a viable payment method.
On the route from Santiago to La Serena, takes approximately 5 hours 35 minutes.
Booking bus tickets between La Serena and Santiago with FlixBus is quick and easy. Simply navigate to the FlixBus website and choose your trip in just three clicks. To find cheap coach tickets, you need to select your city & station of departure and destination, the dates of outgoing & return trips and the number of passengers. The search function will then show you coach trips at the best price, enabling you to reserve your seats and add the trip to your cart before paying for your booking.
Travelers journeying from Santiago to La Serena are entitled to one piece of checked luggage (50x80x30 cm, up to 20 kg) and one hand luggage (30x42x18 cm, up to 7 kg) free of charge. For specifics on extra or unique baggage, consult our luggage policy. Bikes can be ferried on FlixBus, subject to slot availability. Refer to for more information and our bike pricing guide for rates.
Printing is unnecessary for your Santiago to La Serena trip. Online bookers will receive a PDF confirmation via email, embedding a QR code as your ticket. Those using the FlixBus App will have the ticket saved there. Present the digital QR code to the driver upon boarding.
In Santiago, there are 5 coach stops, namely Santiago (Cruce Colon), Santiago (Los Libertadores), Santiago (Pajaritos), Santiago (Terminal Del Sol), Santiago (Terminal San Borja). As for La Serena, it's served by a single stop: La Serena (Bus terminal La Serena). You can locate the FlixBus stops on the embedded map on this page.
For your journey between Santiago and La Serena, stay updated on your coach's whereabouts with our Real-Time Coach Tracker. Choose the relevant coach stop and get the projected arrival details, helping you stay informed about any possible delays.
The first FlixBus service from Santiago to La Serena is scheduled for 06:15.
The day's last FlixBus departure from Santiago to La Serena is at 23:59.
Every FlixBus service between Santiago and La Serena is designed to cater to passengers with mobility constraints. Our commitment is to make journeys as accessible and comfy as feasible for those with mobility challenges or disabilities. All trips between Santiago and La Serena welcome service animals. We accommodate wheelchairs, folding wheelchairs, and other mobility aids at no extra charge.

Searching for coach tickets from Santiago to La Serena?

You're in the right place! Here are all the essentials to organise your coach trip. Travelling from Santiago to La Serena will typically take around 5 hours 35 minutes and can start at a mere £7.99. Coaches set off at 06:15 with the last one departing at 23:59. FlixBus provides 10 services every day between Santiago and La Serena. With FlixBus, benefit from complimentary Wifi, power points, and a reserved seat for your travel.

Steps to secure your coach ticket from Santiago to La Serena

It's straightforward to book with FlixBus. Either on this site or via the free FlixBus App, you can finalise your booking in moments. When buying your ticket from Santiago to La Serena online, we offer multiple secure online payment options, like credit card, Paypal, and even Google and Apple Pay. Or, you can opt for cash on the coach or at an authorised retailer.

Why Opt for FlixBus for Your Journey from Santiago to La Serena?

Uplift your travel game with FlixBus—merging cost-effectiveness with unmatched service. We're eager to have you onboard!

Ample Baggage Provision

Whether you're a light packer or prefer to pack the kitchen sink, we allow one piece of hand luggage and one hold luggage at no extra charge. Want more details? Explore our detailed baggage guidelines.

Journeying with Kids between Santiago and La Serena

We offer reduced rates for youngsters below 15, and pushchairs are brought on free of cost. Dive into our policy for young travellers for further insights.

All-Inclusive Accessibility

Our coach services between Santiago and La Serena are can accommodate passengers with limited mobility. Assistance animals are always welcomed, and we handle the carriage of wheelchairs, collapsible wheelchairs, and other mobility apparatus without any fees.

Facilities Onboard

During your travel between Santiago and La Serena, recline in our roomy seating while enjoyinh free perks such as individual charging points, onboard lavatories, and indeed, complimentary Wi-Fi on most coaches.

Green Travel

Boarding a FlixBus coach nudges you towards a sustainable tomorrow. Tick the CO₂ offset choice during reservation and take comfort in your eco-responsible decision.

Onboard services are subject to availability